Introduction before you come to buy Imidazole CAS 288-32-4

There are only imidazole derivatives in nature, but no free imidazole. What precipitates from benzene is monoclinic prismatic colorless crystals. It smells of ammonia. The relative molecular mass is 68.08. The relative density is 1.0303 (101/4°C). The melting point is 89～91℃, the boiling point is 257℃, 165℃～168℃(2.67×103Pa), 138.2℃(1.60×103Pa). The flash point is 145°C. The refractive index is 1.4801 (101°C). The viscosity is 2.696mPa·s (100°C). Slightly soluble in benzene and petroleum ether, soluble in ether, acetone, chloroform, pyridine, and easily soluble in water (normal temperature 70) and ethanol. Significantly alkaline. Because a hydrogen bond is formed between the -NH-bond at the 1-position and the -N= bond at the 3-position, the boiling point is higher. When the hydrogen at the 1-position is replaced, a hydrogen bond cannot be formed and the boiling point drops. It is thermally stable and hardly decomposes below 250°C (decomposition temperature 590°C). It is also very stable to reducing agents and oxidants, but can form stable salts with inorganic acids. It has certain aromatic properties and can be halogenated, nitrated, sulfonated and hydroxymethylated under the action of a catalyst. And can be coupled with diazonium salt at the 2 position. In addition, since the =NH group (position 1) connects two double bonds, it is somewhat "acidic" and can be replaced by a metal to form a salt. The 3-position nitrogen atom has coordination effect on metal ions and can form chelate. Although it is difficult to be reduced, it can be added to protons to form a cationic and resonant structure, and form a stable form. The tautomers of the imidazole ring are very easy to change, so the isomers at the 4th and 5th positions are not easily distinguished.

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Imidazole (CAS 288-32-4) is an organic compound with the formula (CH)2N(NH)CH. It is a white

Specificaton of Imidazole

Application of Imidazole

1. Mainly used as intermediate in medical industry to produce clotrimazole, miconazole, ketoconazole etc.

2. Imidazole has been used extensively as a corrosion inhibitor on certain transition metals, such as copper. Preventing copper corrosion is important, especially in aqueous systems, where the conductivity of the copper decreases due to corrosion.
3. Used as curing agent for epoxy resin.
4. Used as material for climbazole etc.

5. Imidazole derivatives are valuable in treatment of many systemic fungal infections. Imidazoles belong to the class of azole antifungals, which includes ketoconazole, miconazole, and clotrimazole.

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