Dihydroartemisinin (also known as dihydroqinghaosu, artenimol or DHA) is a drug used to treat malaria. Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs. It is sold commercially in ombination with piperaquine and has been shown to be equivalent to artemether/lumefantrine.
Properties
- Appearance: White Crystal or crystalline powder- Density: 1.24g/cm3
- Boiling Point: 375.6℃ at 760mmHg
- Melting point: 144~149℃
- Flashing Point: 181℃
Specification
Appearance White crystalline powder,odorlessSolubility Easily soluble in water, unsoluble in ethanol
PH 6.0 ~ 7.5
Solution clarity and color Solution should be clear and colorless
Chloride ≤0.05%
Ammonium ≤0.05%
Fe ≤0.01%
Phosphate ≤0.1%
Loss on drying ≤6.0%
Heavy metals ≤0.002%
Arsenide ≤0.0001%
Bacterial Endotoxins ≤0.3EU/mg
Application
Dihydroartemisinin is available as a fixed drug combination with piperaquine (each tablet contains 40 mg of dihydroartemisinin and 320 mg of piperaquine). The adult dose is 1.6/12.8 mg/kg per dose (rounded up or down to the nearest half tablet) given at 0 h, 8 h, 24 h, and 48 h. Alternatively, the same total dose may be given once daily for three days.
Packing
1kg/aluminum foil bag, 25kgs/fiber drum
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