Properties
White Crystal or crystalline powder. Very soluble in actone and chloroform, slightly soluble in ethanol, not soluble in water
-Density: 1.18g/cm3
-Boiling Point: 358℃ at 760mmHg
-Melting point: 86~89℃
-Flashing Point: 141℃
-Refractive Index: 1.518
Specification
Appearance White crystal or crystalline powderSpecific rotation +168.0o~+173.0o
Chloride ≤0.01%
Related substances Simple impurity ≤1.0%
Total other impurity ≤0.5%
Loss on Drying ≤0.5%
Residue on ignition ≤0.1%
Methanol ≤0.5%
Chloroform ≤0.3%
Assay 98.0 ~ 102.0%
Application
Artemether is effective against the blood schizonts of both malarial parasites P. falciparum and P. vivax. It, however, may not be as good as artesunate for severe malaria.
It is available by itself, but usually given in combination with lumefantrine in treatments of malaria. World Health Organization guidelines for the treatment of uncomplicated falciparum malaria recommend the use of this artemisinin-based combination therapy. Zambia was the first African country to adopt artemether/lumefantrine (commonly called Coartem) as first-line therapy in national malaria treatment guidelines in 2002. Clinical records show that by 2008, the rates of in-patient malaria cases and deaths decreased by 61% and 66%, respectively, compared with the 2001-2002 reference period. In South Africa, also, the number of malaria-related outpatient cases and hospital admissions of each fell by 99% from 2001 to 2003, and malaria-related deaths decreased by 97% over the same period.
Packing
1kg/aluminum foil bag, 25kgs/fiber drumStorage
Store in a cool, ventilated place.
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